Single Voxel MRS and Dynamic Contrast Enhancement MR in Differentiating Benign from Malignant Breast Lesions in Iran

Breast cancer is one of the leading causes of death in women all over the world and its prevalence is increasing in many countries. It’s the most common cancer in Iranian women with a mortality rate of 2614 cases per year (Jafari et al., 2014; Sharifian et al., 2015). Early detection of that would be helpful for its successful treatment. Nowadays some techniques such as X-ray mammography, ultrasound and magnetic resonance imaging (MRI) are used for the diagnosis of breast lesions (Kvistad et al., 1999; Katz-Brull et al., 2002). Mammography which is the most common screening method of this disease, has high sensitivity but low specificity especially in low-density breasts. False positive results of mammography is about 60-80%, resulting in many unnecessary biopsies of benign lesions and in some patients there is the likelihood of infections, bleeding and abscess because of biopsy, also the risk of complications from general anesthesia in patients for whom local anesthesia is not possible (Huang et al., 2004). Specificity of ultrasonography to classify benign and malignant lesions has been reported about 30% (Katz-